Drug interactions
Etravirine + Isoniazid
Severity: Minor
Etravirine and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP2C19 and raise etravirine exposure. Etravirine has a wide therapeutic margin, so the clinical effect is probably small, though rash and hepatotoxicity could be additive.
What this interaction means in plain words
Etravirine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP2C19, reducing etravirine metabolism.
What to do
No dose change is usually needed. Monitor liver tests and for rash.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Isoniazid?
MediHelp rates the interaction as minor. Etravirine and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid may inhibit CYP2C19 and raise etravirine exposure. Etravirine has a wide therapeutic margin, so the clinical effect is probably small, though rash and hepatotoxicity could be additive.
How serious is the interaction between Etravirine and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor liver tests and for rash.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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