Drug interactions
Etravirine + Rabeprazole
Severity: Minor
Etravirine and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a weak to moderate CYP3A4 inducer and could modestly lower rabeprazole exposure. Because rabeprazole is largely cleared non-enzymatically, a meaningful loss of acid suppression is unlikely.
What this interaction means in plain words
Etravirine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 induction by etravirine may marginally increase the minor oxidative metabolism of rabeprazole.
What to do
No routine change is needed; reassess acid-suppression response if symptoms persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Rabeprazole?
MediHelp rates the interaction as minor. Etravirine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine is a weak to moderate CYP3A4 inducer and could modestly lower rabeprazole exposure. Because rabeprazole is largely cleared non-enzymatically, a meaningful loss of acid suppression is unlikely.
How serious is the interaction between Etravirine and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; reassess acid-suppression response if symptoms persist.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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