Drug interactions
Etravirine + Rifaximin
Severity: Minor
Etravirine and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine may weakly inhibit P-glycoprotein and could marginally raise rifaximin absorption. Clinical relevance is likely minimal.
What this interaction means in plain words
Etravirine and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Rifaximin belongs to Anti Bacterial.
Why it happens
Weak P-glycoprotein inhibition reducing rifaximin efflux.
What to do
No routine adjustment is needed. Monitor for rifaximin adverse effects only if severe hepatic impairment is present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
- Dronedarone + Rifaximin Moderate
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Rifaximin?
MediHelp rates the interaction as minor. Etravirine and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine may weakly inhibit P-glycoprotein and could marginally raise rifaximin absorption. Clinical relevance is likely minimal.
How serious is the interaction between Etravirine and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for rifaximin adverse effects only if severe hepatic impairment is present.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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