Drug interactions
Etravirine + Tofacitinib
Severity: Moderate
Etravirine and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is an inducer of CYP3A4 and may lower tofacitinib concentrations. This could reduce control of the underlying inflammatory disease. The effect is expected to be weaker than with rifampin.
What this interaction means in plain words
Etravirine and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Tofacitinib belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 increases tofacitinib metabolic clearance.
What to do
Monitor for loss of clinical response to tofacitinib and consider an alternative if disease control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Tofacitinib?
MediHelp rates the interaction as moderate. Etravirine and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is an inducer of CYP3A4 and may lower tofacitinib concentrations. This could reduce control of the underlying inflammatory disease. The effect is expected to be weaker than with rifampin.
How serious is the interaction between Etravirine and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of clinical response to tofacitinib and consider an alternative if disease control worsens.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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