Drug interactions
Etravirine + Ulipristal
Severity: Major
Etravirine and Ulipristal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may reduce ulipristal exposure, potentially lowering the effectiveness of emergency contraception.
What this interaction means in plain words
Etravirine and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Etravirine induces CYP3A4, increasing ulipristal metabolism.
What to do
Avoid ulipristal and use a copper intrauterine device, or levonorgestrel with a doubled dose if recommended locally.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Ulipristal?
MediHelp rates the interaction as major. Etravirine and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etravirine induces CYP3A4 and may reduce ulipristal exposure, potentially lowering the effectiveness of emergency contraception.
How serious is the interaction between Etravirine and Ulipristal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ulipristal and use a copper intrauterine device, or levonorgestrel with a doubled dose if recommended locally.
What other medicines interact with Etravirine?
MediHelp also lists interactions of Etravirine with, for example, Efavirenz, Isavuconazole, Amobarbital. The full list is on the Etravirine page.
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