Drug interactions
Exemestane + Letermovir
Severity: Minor
Exemestane and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may raise exemestane plasma concentrations. The clinical consequence is likely modest because exemestane has a wide tolerability margin.
What this interaction means in plain words
Exemestane and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Exemestane belongs to Oncology; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4, which reduces the metabolism of exemestane.
What to do
No dose change is normally needed; monitor for increased exemestane adverse effects such as hot flushes, arthralgia or fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Exemestane and Letermovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Exemestane
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Exemestane with Letermovir?
MediHelp rates the interaction as minor. Exemestane and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir is a moderate CYP3A inhibitor and may raise exemestane plasma concentrations. The clinical consequence is likely modest because exemestane has a wide tolerability margin.
How serious is the interaction between Exemestane and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor for increased exemestane adverse effects such as hot flushes, arthralgia or fatigue.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
