Drug interactions
Exemestane + Ribociclib
Severity: Minor
Exemestane and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4, but exemestane has a wide therapeutic margin and is commonly combined with ribociclib. Any increase in exposure is unlikely to be clinically important.
What this interaction means in plain words
Exemestane and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Exemestane belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, modestly reducing exemestane metabolism.
What to do
No dose adjustment is needed; monitor for usual exemestane adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exemestane
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Exemestane with Ribociclib?
MediHelp rates the interaction as minor. Exemestane and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib inhibits CYP3A4, but exemestane has a wide therapeutic margin and is commonly combined with ribociclib. Any increase in exposure is unlikely to be clinically important.
How serious is the interaction between Exemestane and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for usual exemestane adverse effects.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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