Drug interactions
Exenatide + Losartan
Severity: Minor
Exenatide and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may modestly improve insulin sensitivity and enhance the effect of glucose-lowering drugs. With exenatide this could slightly raise hypoglycemia risk, mainly when other hypoglycemic agents are used.
What this interaction means in plain words
Exenatide and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Exenatide belongs to Endocrine; Losartan belongs to Cardiovascular.
Why it happens
Angiotensin II receptor blockade may improve insulin sensitivity, adding to exenatide's glucose-lowering effect.
What to do
Monitor glycemic control when losartan is started or stopped. Adjust sulfonylurea or insulin doses if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Exenatide with Losartan?
MediHelp rates the interaction as minor. Exenatide and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may modestly improve insulin sensitivity and enhance the effect of glucose-lowering drugs. With exenatide this could slightly raise hypoglycemia risk, mainly when other hypoglycemic agents are used.
How serious is the interaction between Exenatide and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when losartan is started or stopped. Adjust sulfonylurea or insulin doses if hypoglycemia develops.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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