Drug interactions
Exenatide injectable + Hydrochlorothiazide-lisinopril
Severity: Minor
Exenatide injectable and Hydrochlorothiazide-lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can worsen glucose tolerance and may weaken the glucose-lowering effect of exenatide. The effect is generally small but can matter when thiazide therapy is started or the dose is raised.
What this interaction means in plain words
Exenatide injectable and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides reduce insulin sensitivity and secretion, partly via hypokalemia, opposing the glycemic effect of exenatide.
What to do
Monitor glycemic control when the thiazide is started, stopped or changed, and adjust the antidiabetic regimen if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Exenatide injectable with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as minor. Exenatide injectable and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can worsen glucose tolerance and may weaken the glucose-lowering effect of exenatide. The effect is generally small but can matter when thiazide therapy is started or the dose is raised.
How serious is the interaction between Exenatide injectable and Hydrochlorothiazide-lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when the thiazide is started, stopped or changed, and adjust the antidiabetic regimen if needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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