Drug interactions
Exenatide injectable + Insulin glargine
Severity: Moderate
Exenatide injectable and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide combined with insulin gives additive glucose lowering and a greater likelihood of hypoglycemia. Exenatide also slows gastric emptying, which may alter glycemic patterns.
What this interaction means in plain words
Exenatide injectable and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect of a GLP-1 receptor agonist (glucose-dependent insulin secretion, glucagon suppression) with exogenous insulin.
What to do
Monitor blood glucose frequently when starting exenatide and consider reducing the insulin glargine dose to prevent hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Exenatide injectable with Insulin glargine?
MediHelp rates the interaction as moderate. Exenatide injectable and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide combined with insulin gives additive glucose lowering and a greater likelihood of hypoglycemia. Exenatide also slows gastric emptying, which may alter glycemic patterns.
How serious is the interaction between Exenatide injectable and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting exenatide and consider reducing the insulin glargine dose to prevent hypoglycemia.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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