Drug interactions
Ezogabine + Fluoxetine
Severity: Moderate
Ezogabine and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, and fluoxetine may contribute an additional small effect. Combined use may increase the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Ezogabine and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check an ECG at baseline and after dose titration of ezogabine, and correct electrolyte abnormalities. Reassess the combination if QTc rises substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Fluoxetine?
MediHelp rates the interaction as moderate. Ezogabine and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation, and fluoxetine may contribute an additional small effect. Combined use may increase the risk of arrhythmia in susceptible patients.
How serious is the interaction between Ezogabine and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG at baseline and after dose titration of ezogabine, and correct electrolyte abnormalities. Reassess the combination if QTc rises substantially.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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