Drug interactions
Ezogabine + Fluticasone-vilanterol
Severity: Moderate
Ezogabine and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation and vilanterol may add to cardiac effects. Combined use could raise the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Ezogabine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QTc prolongation, with adrenergic effects of the beta-agonist.
What to do
Check a baseline ECG and monitor QTc and electrolytes during combined therapy. Consider alternative anticonvulsants in patients with cardiac conduction problems.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ezogabine and Fluticasone-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Ezogabine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation and vilanterol may add to cardiac effects. Combined use could raise the risk of arrhythmia in susceptible patients.
How serious is the interaction between Ezogabine and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc and electrolytes during combined therapy. Consider alternative anticonvulsants in patients with cardiac conduction problems.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
