Drug interactions
Ezogabine + Histrelin
Severity: Moderate
Ezogabine and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as histrelin may prolong the QT interval. Combined with ezogabine, which has a modest QT effect, the risk of torsades de pointes may rise.
What this interaction means in plain words
Ezogabine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Histrelin belongs to Musculoskeletal.
Why it happens
Additive effects on cardiac repolarization.
What to do
Monitor the ECG and electrolytes, especially in patients with other QT risk factors. Consider alternatives if the QT interval lengthens substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Ezogabine with Histrelin?
MediHelp rates the interaction as moderate. Ezogabine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as histrelin may prolong the QT interval. Combined with ezogabine, which has a modest QT effect, the risk of torsades de pointes may rise.
How serious is the interaction between Ezogabine and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes, especially in patients with other QT risk factors. Consider alternatives if the QT interval lengthens substantially.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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