Drug interactions
Ezogabine + Levofloxacin
Severity: Moderate
Ezogabine and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, and levofloxacin may add to this effect. Combined use may increase the risk of ventricular arrhythmia, especially at higher ezogabine doses.
What this interaction means in plain words
Ezogabine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization.
What to do
Monitor the ECG when the two are given together and correct electrolyte abnormalities. Choose an alternative antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Levofloxacin?
MediHelp rates the interaction as moderate. Ezogabine and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation, and levofloxacin may add to this effect. Combined use may increase the risk of ventricular arrhythmia, especially at higher ezogabine doses.
How serious is the interaction between Ezogabine and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG when the two are given together and correct electrolyte abnormalities. Choose an alternative antibiotic in patients with other QT risk factors.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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