Drug interactions
Ezogabine + Maprotiline
Severity: Moderate
Ezogabine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT interval prolongation, and maprotiline may also prolong repolarization, so the combination may add to arrhythmia risk. Ezogabine also commonly causes urinary retention and sedation, which maprotiline can worsen through anticholinergic and sedative effects.
What this interaction means in plain words
Ezogabine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with additive sedative and anticholinergic effects.
What to do
Obtain a baseline ECG and monitor the QT interval, particularly during ezogabine titration and in patients with cardiac risk factors. Monitor for urinary retention and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Maprotiline?
MediHelp rates the interaction as moderate. Ezogabine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT interval prolongation, and maprotiline may also prolong repolarization, so the combination may add to arrhythmia risk. Ezogabine also commonly causes urinary retention and sedation, which maprotiline can worsen through anticholinergic and sedative effects.
How serious is the interaction between Ezogabine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QT interval, particularly during ezogabine titration and in patients with cardiac risk factors. Monitor for urinary retention and sedation.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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