Drug interactions
Ezogabine + Propafenone
Severity: Moderate
Ezogabine and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, and propafenone prolongs cardiac conduction and may cause ventricular arrhythmias. Combined use could increase the risk of serious arrhythmia. Ezogabine has also been withdrawn from many markets.
What this interaction means in plain words
Ezogabine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and conduction.
What to do
Obtain a baseline and follow-up ECG and monitor electrolytes if both drugs are required. Prefer an alternative antiseizure drug if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Propafenone?
MediHelp rates the interaction as moderate. Ezogabine and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation, and propafenone prolongs cardiac conduction and may cause ventricular arrhythmias. Combined use could increase the risk of serious arrhythmia. Ezogabine has also been withdrawn from many markets.
How serious is the interaction between Ezogabine and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and follow-up ECG and monitor electrolytes if both drugs are required. Prefer an alternative antiseizure drug if the patient has other QT risk factors.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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