Drug interactions
Ezogabine + Quetiapine
Severity: Moderate
Ezogabine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT interval prolongation, and quetiapine can also prolong QT, so the combination may increase the risk of ventricular arrhythmias. Ezogabine has also been withdrawn from most markets, limiting its current use.
What this interaction means in plain words
Ezogabine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization leading to QT prolongation.
What to do
Obtain a baseline ECG and monitor the QT interval, and correct potassium and magnesium abnormalities. Avoid the combination in patients with congenital long QT or other significant QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Quetiapine?
MediHelp rates the interaction as moderate. Ezogabine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT interval prolongation, and quetiapine can also prolong QT, so the combination may increase the risk of ventricular arrhythmias. Ezogabine has also been withdrawn from most markets, limiting its current use.
How serious is the interaction between Ezogabine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QT interval, and correct potassium and magnesium abnormalities. Avoid the combination in patients with congenital long QT or other significant QT risk factors.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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