Drug interactions
Ezogabine + Quinidine
Severity: Major
Ezogabine and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine can prolong the QT interval and quinidine strongly does so too, so combined use may increase the risk of torsades de pointes. Ezogabine labeling advises ECG monitoring with QT-prolonging drugs.
What this interaction means in plain words
Ezogabine and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization (pharmacodynamic).
What to do
Avoid if an alternative exists. If used together, monitor ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Quinidine?
MediHelp rates the interaction as major. Ezogabine and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ezogabine can prolong the QT interval and quinidine strongly does so too, so combined use may increase the risk of torsades de pointes. Ezogabine labeling advises ECG monitoring with QT-prolonging drugs.
How serious is the interaction between Ezogabine and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. If used together, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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