Drug interactions
Ezogabine + Quizartinib
Severity: Major
Ezogabine and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may add to the risk of serious ventricular arrhythmias including torsades de pointes. Quizartinib carries a boxed warning for QT prolongation, which makes any additional QT-active drug more concerning.
What this interaction means in plain words
Ezogabine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Quizartinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QTc) through pharmacodynamic effects.
What to do
Avoid the combination if possible; if unavoidable, obtain baseline and serial ECGs and keep potassium and magnesium within normal range. Reduce the quizartinib dose or stop a drug if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ezogabine
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Ezogabine with Quizartinib?
MediHelp rates the interaction as major. Ezogabine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so using them together may add to the risk of serious ventricular arrhythmias including torsades de pointes. Quizartinib carries a boxed warning for QT prolongation, which makes any additional QT-active drug more concerning.
How serious is the interaction between Ezogabine and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if unavoidable, obtain baseline and serial ECGs and keep potassium and magnesium within normal range. Reduce the quizartinib dose or stop a drug if QTc rises significantly.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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