Drug interactions
Ezogabine + Thioridazine
Severity: Major
Ezogabine and Thioridazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lengthen the QT interval, and thioridazine does so strongly, with a risk of torsades de pointes. Ezogabine is also associated with sedation and urinary retention, and the QT effect adds to thioridazine risk. The combination raises the chance of serious ventricular arrhythmia.
What this interaction means in plain words
Ezogabine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation, with additive CNS depression.
What to do
Avoid the combination if possible. If it is necessary, obtain a baseline and follow-up ECG, correct potassium and magnesium, and stop if QTc increases significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Thioridazine?
MediHelp rates the interaction as major. Ezogabine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can lengthen the QT interval, and thioridazine does so strongly, with a risk of torsades de pointes. Ezogabine is also associated with sedation and urinary retention, and the QT effect adds to thioridazine risk. The combination raises the chance of serious ventricular arrhythmia.
How serious is the interaction between Ezogabine and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is necessary, obtain a baseline and follow-up ECG, correct potassium and magnesium, and stop if QTc increases significantly.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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