Drug interactions
Ezogabine + Umeclidinium-vilanterol
Severity: Moderate
Ezogabine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation and can cause urinary retention. Combined with vilanterol cardiac effects and umeclidinium anticholinergic effects, the risk of arrhythmia and urinary retention may rise.
What this interaction means in plain words
Ezogabine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation, beta-agonist cardiac stimulation and anticholinergic urinary effects.
What to do
Monitor ECG and urinary symptoms. Correct electrolyte abnormalities and consider alternatives in patients with cardiac or urinary risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Ezogabine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation and can cause urinary retention. Combined with vilanterol cardiac effects and umeclidinium anticholinergic effects, the risk of arrhythmia and urinary retention may rise.
How serious is the interaction between Ezogabine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and urinary symptoms. Correct electrolyte abnormalities and consider alternatives in patients with cardiac or urinary risk factors.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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