Drug interactions
Ezogabine + Voclosporin
Severity: Moderate
Ezogabine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QTc interval at supratherapeutic exposures, and ezogabine has a modest QT effect. Combined use may increase the risk of arrhythmia, although the clinical data are limited.
What this interaction means in plain words
Ezogabine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization.
What to do
Monitor ECG and electrolytes at baseline and periodically in patients with additional QT risk factors. Reassess the combination if the QTc rises markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ezogabine with Voclosporin?
MediHelp rates the interaction as moderate. Ezogabine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QTc interval at supratherapeutic exposures, and ezogabine has a modest QT effect. Combined use may increase the risk of arrhythmia, although the clinical data are limited.
How serious is the interaction between Ezogabine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically in patients with additional QT risk factors. Reassess the combination if the QTc rises markedly.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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