Drug interactions
Ezogabine + Ziprasidone
Severity: Major
Ezogabine and Ziprasidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, and ziprasidone also prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Ezogabine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ezogabine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization leading to QT prolongation.
What to do
Avoid the combination where possible. If it is unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the ECG during dose titration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Ziprasidone?
MediHelp rates the interaction as major. Ezogabine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ezogabine has been associated with QT prolongation, and ziprasidone also prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Ezogabine and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the ECG during dose titration.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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