Drug interactions
Factor x human + Fondaparinux
Severity: Moderate
Factor x human and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fondaparinux inhibits factor Xa and can counteract the procoagulant effect of replacement factor X. Hemostatic efficacy of factor X concentrate may therefore be reduced in a patient who is anticoagulated.
What this interaction means in plain words
Factor x human and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: antithrombin-mediated factor Xa inhibition opposes the supplied factor X.
What to do
Avoid giving fondaparinux to patients being treated with factor X for a bleeding disorder unless clearly needed. Monitor hemostasis and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Factor x human with Fondaparinux?
MediHelp rates the interaction as moderate. Factor x human and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fondaparinux inhibits factor Xa and can counteract the procoagulant effect of replacement factor X. Hemostatic efficacy of factor X concentrate may therefore be reduced in a patient who is anticoagulated.
How serious is the interaction between Factor x human and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving fondaparinux to patients being treated with factor X for a bleeding disorder unless clearly needed. Monitor hemostasis and clinical response.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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