Drug interactions
Factor x human + Rivaroxaban
Severity: Moderate
Factor x human and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Human factor X replacement is intended to restore coagulation in factor X deficiency, whereas rivaroxaban directly inhibits activated factor X. The anticoagulant may counteract the replacement product and vice versa.
What this interaction means in plain words
Factor x human and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: rivaroxaban inhibits factor Xa generated from the infused factor X.
What to do
Avoid routine co-use; if both are clinically needed, monitor coagulation status and clinical response and review the indication for anticoagulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Factor x human with Rivaroxaban?
MediHelp rates the interaction as moderate. Factor x human and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Human factor X replacement is intended to restore coagulation in factor X deficiency, whereas rivaroxaban directly inhibits activated factor X. The anticoagulant may counteract the replacement product and vice versa.
How serious is the interaction between Factor x human and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-use; if both are clinically needed, monitor coagulation status and clinical response and review the indication for anticoagulation.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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