Drug interactions
Famotidine + Gliclazide
Severity: Minor
Famotidine and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which could theoretically affect sulfonylurea absorption, but no clinically meaningful effect on gliclazide is documented. Unlike cimetidine, famotidine does not inhibit CYP enzymes.
What this interaction means in plain words
Famotidine and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Gliclazide belongs to Endocrine.
Why it happens
Altered gastric pH may marginally change absorption; the effect is theoretical.
What to do
No routine adjustment is required. Monitor glucose if control changes unexpectedly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Gliclazide?
MediHelp rates the interaction as minor. Famotidine and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine raises gastric pH, which could theoretically affect sulfonylurea absorption, but no clinically meaningful effect on gliclazide is documented. Unlike cimetidine, famotidine does not inhibit CYP enzymes.
How serious is the interaction between Famotidine and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor glucose if control changes unexpectedly.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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