Drug interactions
Famotidine + Glipizide-metformin
Severity: Minor
Famotidine and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine has little clinically relevant effect on glipizide. It is renally cleared through OCT/MATE transporters, so a minor effect on metformin is possible but rarely significant.
What this interaction means in plain words
Famotidine and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Glipizide-metformin belongs to Endocrine.
Why it happens
Higher gastric pH may slightly alter absorption; minor competition for renal transport.
What to do
No routine action beyond usual glucose monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Glipizide-metformin?
MediHelp rates the interaction as minor. Famotidine and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine has little clinically relevant effect on glipizide. It is renally cleared through OCT/MATE transporters, so a minor effect on metformin is possible but rarely significant.
How serious is the interaction between Famotidine and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action beyond usual glucose monitoring.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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