Drug interactions
Famotidine + Glyburide-metformin
Severity: Minor
Famotidine and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may slightly increase glyburide effects, but changes are small and rarely clinically relevant. Famotidine is renally cleared by OCT/MATE transporters, but no meaningful metformin effect is expected at usual doses.
What this interaction means in plain words
Famotidine and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Glyburide-metformin belongs to Endocrine.
Why it happens
Higher gastric pH may modestly change glyburide absorption.
What to do
No dose adjustment is usually needed; monitor blood glucose if therapy changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Glyburide-metformin?
MediHelp rates the interaction as minor. Famotidine and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine may slightly increase glyburide effects, but changes are small and rarely clinically relevant. Famotidine is renally cleared by OCT/MATE transporters, but no meaningful metformin effect is expected at usual doses.
How serious is the interaction between Famotidine and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor blood glucose if therapy changes.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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