Drug interactions
Famotidine + Metformin-pioglitazone
Severity: Minor
Famotidine and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine is renally secreted through cationic transporters and may slightly raise metformin levels. The change is small and rarely clinically relevant in patients with normal kidney function.
What this interaction means in plain words
Famotidine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Possible competition for renal tubular cationic transport (OCT2/MATE) reduces metformin clearance.
What to do
No routine adjustment is needed; monitor glucose control and renal function, especially in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Famotidine and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine is renally secreted through cationic transporters and may slightly raise metformin levels. The change is small and rarely clinically relevant in patients with normal kidney function.
How serious is the interaction between Famotidine and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor glucose control and renal function, especially in patients with renal impairment.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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