Drug interactions
Famotidine + Metformin-repaglinide
Severity: Minor
Famotidine and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may slightly raise metformin exposure by competing for renal tubular secretion. The effect is small and rarely clinically important unless renal function is impaired.
What this interaction means in plain words
Famotidine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Metformin-repaglinide belongs to Endocrine.
Why it happens
Competition for renal tubular cationic transport reduces metformin clearance.
What to do
No routine adjustment is needed. Monitor renal function and glycemic response in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Metformin-repaglinide?
MediHelp rates the interaction as minor. Famotidine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine may slightly raise metformin exposure by competing for renal tubular secretion. The effect is small and rarely clinically important unless renal function is impaired.
How serious is the interaction between Famotidine and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and glycemic response in patients with renal impairment.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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