Drug interactions
Famotidine + Nelfinavir
Severity: Moderate
Famotidine and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir needs acid for good absorption, so famotidine may decrease its levels. This may lessen antiviral effect.
What this interaction means in plain words
Famotidine and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Nelfinavir belongs to Anti Virals.
Why it happens
Raised gastric pH reduces nelfinavir absorption.
What to do
Monitor HIV viral load and consider timing nelfinavir apart from the H2 blocker. Take nelfinavir with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Famotidine with Nelfinavir?
MediHelp rates the interaction as moderate. Famotidine and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir needs acid for good absorption, so famotidine may decrease its levels. This may lessen antiviral effect.
How serious is the interaction between Famotidine and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider timing nelfinavir apart from the H2 blocker. Take nelfinavir with food.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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