Drug interactions
Famotidine + Sofosbuvir-velpatasvir
Severity: Moderate
Famotidine and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH and may reduce velpatasvir absorption. At standard doses the effect is limited if timing is respected.
What this interaction means in plain words
Famotidine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Higher gastric pH decreases velpatasvir solubility.
What to do
Give the H2 blocker at the same time as or 12 hours apart from the antiviral, not exceeding famotidine 40 mg twice daily equivalent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Famotidine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine raises gastric pH and may reduce velpatasvir absorption. At standard doses the effect is limited if timing is respected.
How serious is the interaction between Famotidine and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the H2 blocker at the same time as or 12 hours apart from the antiviral, not exceeding famotidine 40 mg twice daily equivalent.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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