Drug interactions
Famotidine + Sotorasib
Severity: Major
Famotidine and Sotorasib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib solubility depends on gastric acidity, and acid-reducing drugs such as famotidine can lower its exposure. This may reduce anticancer efficacy.
What this interaction means in plain words
Famotidine and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Famotidine belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Increased gastric pH reduces the pH-dependent solubility and absorption of sotorasib.
What to do
Avoid concurrent use if possible; if unavoidable, take sotorasib 4 hours before or 10 hours after famotidine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Famotidine
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Famotidine with Sotorasib?
MediHelp rates the interaction as major. Famotidine and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotorasib solubility depends on gastric acidity, and acid-reducing drugs such as famotidine can lower its exposure. This may reduce anticancer efficacy.
How serious is the interaction between Famotidine and Sotorasib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; if unavoidable, take sotorasib 4 hours before or 10 hours after famotidine.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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