Drug interactions
Felodipine + Fludrocortisone
Severity: Moderate
Felodipine and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone causes sodium and fluid retention that can raise blood pressure and counteract felodipine. It has little CYP3A4 induction effect compared with dexamethasone.
What this interaction means in plain words
Felodipine and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Mineralocorticoid-mediated sodium and water retention opposes antihypertensive effect.
What to do
Monitor blood pressure and edema and adjust doses of either drug as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Felodipine with Fludrocortisone?
MediHelp rates the interaction as moderate. Felodipine and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone causes sodium and fluid retention that can raise blood pressure and counteract felodipine. It has little CYP3A4 induction effect compared with dexamethasone.
How serious is the interaction between Felodipine and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema and adjust doses of either drug as needed.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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