Drug interactions
Felodipine + Glyburide-metformin
Severity: Minor
Felodipine and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydropyridine calcium channel blockers can occasionally impair glucose tolerance, though the effect with felodipine is usually small. Glucose control rarely changes enough to need action.
What this interaction means in plain words
Felodipine and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Calcium channel blockade may modestly reduce insulin release, and sympathetic activation can raise glucose.
What to do
Monitor blood glucose when felodipine is started or stopped, and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Glyburide-metformin?
MediHelp rates the interaction as minor. Felodipine and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dihydropyridine calcium channel blockers can occasionally impair glucose tolerance, though the effect with felodipine is usually small. Glucose control rarely changes enough to need action.
How serious is the interaction between Felodipine and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when felodipine is started or stopped, and adjust antidiabetic therapy if needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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