Drug interactions
Felodipine + Griseofulvin
Severity: Moderate
Felodipine and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may reduce felodipine concentrations, leading to weaker blood pressure control or reduced antianginal effect. Felodipine is highly dependent on CYP3A4 and is very sensitive to induction.
What this interaction means in plain words
Felodipine and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Griseofulvin belongs to Anti Fungals.
Why it happens
Induction of intestinal and hepatic CYP3A4 increases first-pass and systemic clearance of felodipine.
What to do
Monitor blood pressure and heart rate and titrate felodipine upward if needed. Reassess the dose when griseofulvin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Griseofulvin?
MediHelp rates the interaction as moderate. Felodipine and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may reduce felodipine concentrations, leading to weaker blood pressure control or reduced antianginal effect. Felodipine is highly dependent on CYP3A4 and is very sensitive to induction.
How serious is the interaction between Felodipine and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate felodipine upward if needed. Reassess the dose when griseofulvin is stopped.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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