Drug interactions
Felodipine + Istradefylline
Severity: Moderate
Felodipine and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline raises exposure to CYP3A4 substrates and may increase felodipine levels, with hypotension and edema. The effect is not expected at 20 mg daily.
What this interaction means in plain words
Felodipine and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline weakly inhibits CYP3A4 at higher doses, reducing felodipine metabolism.
What to do
Monitor blood pressure and consider lowering the felodipine dose if istradefylline 40 mg daily is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Felodipine with Istradefylline?
MediHelp rates the interaction as moderate. Felodipine and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily istradefylline raises exposure to CYP3A4 substrates and may increase felodipine levels, with hypotension and edema. The effect is not expected at 20 mg daily.
How serious is the interaction between Felodipine and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider lowering the felodipine dose if istradefylline 40 mg daily is used.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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