Drug interactions
Felodipine + Ivosidenib
Severity: Moderate
Felodipine and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4, which can lower felodipine concentrations. Reduced exposure may lead to loss of blood pressure control.
What this interaction means in plain words
Felodipine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Ivosidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 by ivosidenib increases felodipine metabolism and decreases its plasma levels.
What to do
Monitor blood pressure after starting or stopping ivosidenib and titrate felodipine upward as needed. Use a non-CYP3A4-dependent antihypertensive if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Felodipine with Ivosidenib?
MediHelp rates the interaction as moderate. Felodipine and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4, which can lower felodipine concentrations. Reduced exposure may lead to loss of blood pressure control.
How serious is the interaction between Felodipine and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping ivosidenib and titrate felodipine upward as needed. Use a non-CYP3A4-dependent antihypertensive if control is inadequate.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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