Drug interactions
Felodipine + Lorlatinib
Severity: Moderate
Felodipine and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and can lower exposure to CYP3A substrates such as felodipine, reducing blood pressure control.
What this interaction means in plain words
Felodipine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing felodipine metabolism.
What to do
Monitor blood pressure and raise the felodipine dose if control is lost; reassess after lorlatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Felodipine with Lorlatinib?
MediHelp rates the interaction as moderate. Felodipine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A inducer and can lower exposure to CYP3A substrates such as felodipine, reducing blood pressure control.
How serious is the interaction between Felodipine and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and raise the felodipine dose if control is lost; reassess after lorlatinib is stopped.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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