Drug interactions
Felodipine + Metformin-repaglinide
Severity: Minor
Felodipine and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydropyridine calcium channel blockers may occasionally worsen glucose tolerance, which could blunt the effect of antidiabetic drugs. The effect is usually small and clinically minor.
What this interaction means in plain words
Felodipine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Possible reduction in insulin secretion or sensitivity due to calcium channel blockade; mechanism not well established.
What to do
Monitor blood glucose when felodipine is started or stopped and adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Metformin-repaglinide?
MediHelp rates the interaction as minor. Felodipine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dihydropyridine calcium channel blockers may occasionally worsen glucose tolerance, which could blunt the effect of antidiabetic drugs. The effect is usually small and clinically minor.
How serious is the interaction between Felodipine and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when felodipine is started or stopped and adjust antidiabetic therapy if control changes.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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