Drug interactions
Felodipine + Miconazole
Severity: Moderate
Felodipine and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine undergoes extensive CYP3A4 first-pass metabolism and is very sensitive to CYP3A4 inhibitors. Miconazole may raise felodipine levels, leading to hypotension, flushing, headache and peripheral edema. Vaginal use reduces but does not remove this risk.
What this interaction means in plain words
Felodipine and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits intestinal and hepatic CYP3A4, decreasing felodipine clearance.
What to do
Monitor blood pressure and for edema or dizziness during miconazole therapy. Reduce the felodipine dose if hypotension or marked vasodilatory effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Miconazole?
MediHelp rates the interaction as moderate. Felodipine and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine undergoes extensive CYP3A4 first-pass metabolism and is very sensitive to CYP3A4 inhibitors. Miconazole may raise felodipine levels, leading to hypotension, flushing, headache and peripheral edema. Vaginal use reduces but does not remove this risk.
How serious is the interaction between Felodipine and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or dizziness during miconazole therapy. Reduce the felodipine dose if hypotension or marked vasodilatory effects occur.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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