Drug interactions
Felodipine + Nelfinavir
Severity: Major
Felodipine and Nelfinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can substantially raise felodipine concentrations, leading to hypotension, edema, flushing and tachycardia. Felodipine may slightly affect nelfinavir transport, which is of little consequence.
What this interaction means in plain words
Felodipine and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Felodipine belongs to Cardiovascular; Nelfinavir belongs to Anti Virals.
Why it happens
Nelfinavir inhibits CYP3A4-mediated felodipine metabolism, increasing felodipine exposure.
What to do
Start with a low felodipine dose and titrate by blood pressure response, or choose an alternative antihypertensive. Monitor for edema and hypotension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Felodipine and Nelfinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Felodipine with Nelfinavir?
MediHelp rates the interaction as major. Felodipine and Nelfinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelfinavir inhibits CYP3A4 and can substantially raise felodipine concentrations, leading to hypotension, edema, flushing and tachycardia. Felodipine may slightly affect nelfinavir transport, which is of little consequence.
How serious is the interaction between Felodipine and Nelfinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low felodipine dose and titrate by blood pressure response, or choose an alternative antihypertensive. Monitor for edema and hypotension.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
