Drug interactions
Felodipine + Nifedipine
Severity: Moderate
Felodipine and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dihydropyridine calcium channel blockers, so combining them duplicates therapy and increases the risk of hypotension, flushing, headache and peripheral edema. Competition for CYP3A4 metabolism may further increase exposure.
What this interaction means in plain words
Felodipine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade with possible competition for CYP3A4 metabolism.
What to do
Avoid combining two dihydropyridines; use a single agent or add a drug from a different class. If both are continued, monitor blood pressure and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Nifedipine?
MediHelp rates the interaction as moderate. Felodipine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dihydropyridine calcium channel blockers, so combining them duplicates therapy and increases the risk of hypotension, flushing, headache and peripheral edema. Competition for CYP3A4 metabolism may further increase exposure.
How serious is the interaction between Felodipine and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines; use a single agent or add a drug from a different class. If both are continued, monitor blood pressure and edema.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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