Drug interactions
Felodipine + Rocuronium
Severity: Minor
Felodipine and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can modestly enhance and prolong the neuromuscular blockade produced by non-depolarizing agents such as rocuronium. The effect is usually small, but recovery may be slower than expected.
What this interaction means in plain words
Felodipine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Rocuronium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade may reduce presynaptic acetylcholine release and so add to the postsynaptic block of rocuronium.
What to do
Monitor neuromuscular function with train-of-four during anesthesia and titrate rocuronium to response. Make sure recovery is complete before extubation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rocuronium
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Rocuronium?
MediHelp rates the interaction as minor. Felodipine and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can modestly enhance and prolong the neuromuscular blockade produced by non-depolarizing agents such as rocuronium. The effect is usually small, but recovery may be slower than expected.
How serious is the interaction between Felodipine and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four during anesthesia and titrate rocuronium to response. Make sure recovery is complete before extubation.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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