Drug interactions
Felodipine + Vincristine
Severity: Moderate
Felodipine and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may inhibit P-glycoprotein and increase vincristine exposure, though evidence is limited. Greater exposure could worsen peripheral neuropathy and constipation.
What this interaction means in plain words
Felodipine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Vincristine belongs to Oncology.
Why it happens
Possible P-glycoprotein inhibition by felodipine reduces vincristine efflux.
What to do
Monitor for neurotoxicity and constipation during treatment. Consider an alternative antihypertensive if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Felodipine with Vincristine?
MediHelp rates the interaction as moderate. Felodipine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine may inhibit P-glycoprotein and increase vincristine exposure, though evidence is limited. Greater exposure could worsen peripheral neuropathy and constipation.
How serious is the interaction between Felodipine and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity and constipation during treatment. Consider an alternative antihypertensive if toxicity emerges.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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