Drug interactions
Fenbufen + Fluvoxamine
Severity: Moderate
Fenbufen and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen inhibit platelet function and irritate the gastric lining, and SSRIs add to the impairment of platelet aggregation. The combination raises the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Fenbufen and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction from SSRI-reduced platelet serotonin and NSAID COX inhibition, with NSAID mucosal injury.
What to do
Use the lowest effective NSAID dose for the shortest time, consider gastroprotection with a proton pump inhibitor, and monitor for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fenbufen with Fluvoxamine?
MediHelp rates the interaction as moderate. Fenbufen and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen inhibit platelet function and irritate the gastric lining, and SSRIs add to the impairment of platelet aggregation. The combination raises the risk of gastrointestinal and other bleeding.
How serious is the interaction between Fenbufen and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, consider gastroprotection with a proton pump inhibitor, and monitor for GI bleeding.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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