Drug interactions
Fenbufen + Fondaparinux
Severity: Moderate
Fenbufen and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen is an NSAID that reduces platelet function and can cause gastrointestinal injury. With fondaparinux the risk of bleeding increases.
What this interaction means in plain words
Fenbufen and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects: NSAID platelet inhibition and mucosal injury plus factor Xa inhibition.
What to do
Avoid if possible, or use the lowest effective dose briefly with gastroprotection. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fenbufen with Fondaparinux?
MediHelp rates the interaction as moderate. Fenbufen and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen is an NSAID that reduces platelet function and can cause gastrointestinal injury. With fondaparinux the risk of bleeding increases.
How serious is the interaction between Fenbufen and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use the lowest effective dose briefly with gastroprotection. Monitor for bleeding.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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