Drug interactions
Fenbufen + Labetalol
Severity: Moderate
Fenbufen and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can reduce the antihypertensive effect of beta-blockers by inhibiting prostaglandin synthesis, causing sodium and fluid retention. Blood pressure control may worsen with regular use, and NSAIDs can also impair renal function.
What this interaction means in plain words
Fenbufen and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal vasodilatory prostaglandins leads to sodium and water retention, opposing the antihypertensive effect of labetalol.
What to do
Monitor blood pressure when fenbufen is used regularly with labetalol, and use the lowest effective NSAID dose for the shortest time. Consider alternative analgesia such as paracetamol if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Fenbufen with Labetalol?
MediHelp rates the interaction as moderate. Fenbufen and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can reduce the antihypertensive effect of beta-blockers by inhibiting prostaglandin synthesis, causing sodium and fluid retention. Blood pressure control may worsen with regular use, and NSAIDs can also impair renal function.
How serious is the interaction between Fenbufen and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when fenbufen is used regularly with labetalol, and use the lowest effective NSAID dose for the shortest time. Consider alternative analgesia such as paracetamol if control is lost.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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