Drug interactions
Fenbufen + Losartan
Severity: Moderate
Fenbufen and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can blunt the antihypertensive effect of losartan and impair renal function, especially in elderly, dehydrated or renally impaired patients. Hyperkalemia risk is also increased.
What this interaction means in plain words
Fenbufen and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion, sodium excretion and potassium excretion, counteracting ARB effects.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium, particularly at initiation. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Fenbufen with Losartan?
MediHelp rates the interaction as moderate. Fenbufen and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can blunt the antihypertensive effect of losartan and impair renal function, especially in elderly, dehydrated or renally impaired patients. Hyperkalemia risk is also increased.
How serious is the interaction between Fenbufen and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium, particularly at initiation. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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