Drug interactions
Fenofibrate micronized + Insulin glargine
Severity: Minor
Fenofibrate micronized and Insulin glargine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate has been associated with improved glycemic measures in some patients with diabetes, and combining it with insulin may occasionally lower glucose more than expected. The clinical effect is usually small, but hypoglycemia is possible in patients on tight insulin regimens.
What this interaction means in plain words
Fenofibrate micronized and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not well established; fenofibrate may modestly improve insulin sensitivity through PPAR-alpha activation.
What to do
Monitor blood glucose when fenofibrate is started or stopped and reduce the insulin glargine dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Fenofibrate micronized with Insulin glargine?
MediHelp rates the interaction as minor. Fenofibrate micronized and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate has been associated with improved glycemic measures in some patients with diabetes, and combining it with insulin may occasionally lower glucose more than expected. The clinical effect is usually small, but hypoglycemia is possible in patients on tight insulin regimens.
How serious is the interaction between Fenofibrate micronized and Insulin glargine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fenofibrate is started or stopped and reduce the insulin glargine dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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